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Q : Risk factors of penicillin in leptospirosis?
A : mild leptospirosis is treated with doxycyline,ampicillin or amoxicillin.for severe lepto,iv penicillin G is drug of choice
Iv penicillin is effective but may not prevent the development of renal failure.parenteral ceftriaxone is as effective as penicillin.Jarish-Herxheimer reaction may occur during treatment but usually mild..
following penicillin treatment spirochetal diseases, a substantial proportion of patients may develop Jarisch-Herxheimer (JH) reaction, a syndrome composed of some of the following features: abrupt onset of fever, chills, myalgias, tachycardia, vasodilatation with flushing, exacerbated skin rash, or mild hypertension
[definition of jarisch-herxheimer rxn]
🐀 a transient, short term immunologic reaction commonly seen following antibiotic treatment of early and late stage of syphilis and less often in other disease, such as borreliosis, thypoid fever. 🐀manifestation include fever, chills, headache, myalgia, and exacerbation of cutaneous lesions.
🐀attributed to liberation of endotoxin-like substance or antigen from killed or dying microorganism, but its exact pathogenesis is unclear..
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